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مقالات فارسیISIکنفرانسهاژورنالها

Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum

محل انتشار: مجله میکروبیولوژی پزشکی و بیماریهای عفونی، دوره: 7، شماره: 3
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 35

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لینک ثابت به این مقاله:
https://civilica.com/doc/1917684

شناسه ملی سند علمی:

JR_JMMI-7-3_003

تاریخ نمایه سازی: 29 بهمن 1402

چکیده مقاله:

Introduction: Leishmaniasis is a severe disease that presents a real public health problem worldwide. Antileishmanial therapy remains expensive with intolerable side effects; therefore, it is essential to develop tolerable antileishmanial medications with a selective efficacy. Methods: In this study,  the leishmanicidal activities of seven Algerian plant extracts, selected based on either ethnobotanical or chemotaxonomical data, were screened for their antileishmanial activity against promastigotes and amastigotes of cutaneous leishmaniasis agent Leishmania major (MON ۲۵), and visceral leishmaniasis agent Leishmania infantum (MON ۱). The cytotoxic activity against human monocytes THP۱ was also determined. Results: In both species, amastigotes showed more sensitivity to the extracts than promastigotes. Erica arborea flower (IC۵۰=۴۳,۹۸ 𝜇g/mL), Marrubium vulgare leaves (IC۵۰=۴۵,۸۴ 𝜇g/mL) and Artemisia herba-alba Asso aerial parts (IC۵۰=۵۵,۲۱ 𝜇g/mL) had an almost similar inhibitory effect on L. major promastigote. Marrubium vulgare leaves (IC۵۰=۳۵,۶۳ 𝜇g/mL) was most effective against L. infantum promastigotes. Besides, these extracts exhibited low selectivity indices. The best results were obtained with M. vulgare on both L. major and L. infantum promastigotes (IC۵۰s of ۴۵,۸۴ µg/ml and ۳۵,۶۳ µg/ml), and amastigotes (IC۵۰s of ۳۲,۱۵ µg/ml and ۱۸,۶۴ µg/ml). The selectivity index was above two (۲.۳۴ for L. major and ۳.۰۱ for L. infantum), calculated based on the acceptable cytotoxic effect of M. vulgare on human macrophage cell line (CC۵۰=۱۰۷,۴۵ µg/ml). Conclusion: Out of the seven methanol extracts tested against promastigotes of L. major and L. infantum, three showed promising activity with potent leishmanicidal effect and acceptable selectivity indices on L. major and L. infantum.

کلیدواژه ها:

Leishmanicidal effect ، Medicinal plant ، Algeria ، Leishmaniasis.

نویسندگان

Naouel Eddaikra

Laboratory of Eco-epidemiology Parasitology and Populations Genetics, Institute Pasteur of Algeria, Route du Petit Staoueli Dely Brahim Algiers, Algeria

Amel Boudjelal

University Mohamed BOUDIAF of M’sila, M’Sila, Algeria

Mohamed Amine Sbabdji

University Saad DAHLEB of Blida, Blida, Algeria

Atika Eddaikra

University Saad DAHLEB of Blida, Blida, Algeria

Abdelkrim Boudrissa

University Mohamed BOUDIAF of M’sila, M’Sila, Algeria

Mustapha Mounir Bouhenna

Research Center in Physical and Chemical Analysis (CRAPC), BP ۳۸۴, Bou-Ismail, RP ۴۲۰۰۴, Tipaza, Algeria

Smain Chemat

Research Center in Physical and Chemical Analysis (CRAPC), BP ۳۸۴, Bou-Ismail, RP ۴۲۰۰۴, Tipaza, Algeria

Zoubir Harrat

Laboratory of Eco-epidemiology Parasitology and Populations Genetics, Institute Pasteur of Algeria, Route du Petit Staoueli Dely Brahim Algiers, Algeria

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