Investigation into the Antibacterial Activity of Metal Complexes Derived from Substituted Chromone in Comparison with Tetracycline, and Cephradine as Standard Drugs against Escherichia coli and Staphylococcus aureus
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 28
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شناسه ملی سند علمی:
JR_JMMI-3-3_008
تاریخ نمایه سازی: 29 بهمن 1402
چکیده مقاله:
Introduction: The chemistry of metal complexes derived from heterocyclic compounds has attracted considerable interest due to the broad range of pharmacological activities of such compounds. The important pathogens such as Escherichia coli, and Staphylococcus aureus are wildly caused many diseases. So antibacterial activity of Zn (Ⅱ), Ni (Ⅱ), Co (Ⅱ) and Cu (Ⅱ) chromone complexes against two kinds of bacteria was established. Methods: In this study, antibacterial activity of metal complexes derived from ۲-amino-۷, ۷-dimethyl-۵-oxo-۴-methylbenzen۵, ۶, ۷, ۸-tetra hydro-۴H-chromone-۳-carbonitrile were studied. The metal complexes were characterized by FTIR, UV-Vis and Mass spectroscopy. Antibacterial effect of these compounds was evaluated by disc diffusion and micro broth dilution methods. Results: The results obtained in this study demonstrate that all the complexes have square planner geometry with the stoichiometry ۱:۲ (Metal: Ligand). Among the tested compounds the most effective compound was the Cu complex with MIC value of ۶۲.۵ mg/mL against E. coli and ۱۲۵ mg/mL against S. aureus. Conclusion: The results of these studies show that metal the metal complexes had higher antibacterial activity against species when compared to parent ligand.
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نویسندگان
Hoda Pasdar
islamic azad university, tehran north branch
Naser Foroughifar
islamic azad university, tehran north branch
Bahare Hedayati Saghavaz
islamic azad university, tehran north branch
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