Comparison of Pregnancy-Associated Plasma Protein-A Levels in Women with and Without Intrauterine Growth Restriction

Background and objective:   The initial diagnosis of predictive markers is essential for the IUGR. High levels of PAPP-A lead to increased levels of free IGF-۱, which in turn reflects the function of the placenta and the fetus normal growth. The objective of this study was to compare the level of PAPP-A in pregnancy weeks ۱۱-۱۴ in women with and without intrauterine growth restriction and to assess the ability of this marker to predict adverse outcomes in pregnancy. Methods:  In this Comparative Cross-sectional study, ۲۲۷ pregnant women were studied during ۲۰۱۷. Mothers were divided into two main groups with and without intrauterine growth restriction. The relevant data, including birth weight, preeclampsia, gestational diabetes, Apgar score, and PAPP-A, were recorded on special forms. Data analysis was done using SPSS-۲۱ software. Results: The mean age of participating women in this study was ۲۸.۸ ± ۵.۶ years. The median (IOR) number of gravidity and Gestational weight gain was ۱ (۱) and ۱۲ (۷) kg respectively. The difference in median (IOR) PAPP-A in patients with and without IUGR was statistically significant ۰.۶۴(۰.۵۷) and ۱ (۰.۵۷), respectively, P= ۰.۰۰۱.The cut-off point for PAPP-A was ۰.۷۳ with a sensitivity=۷۲.۲% (۹۵% CI: ۶۴.۳۲-۷۹.۱۶%) and a specify =۶۰.۵% (۹۵% CI: ۴۸.۶۵ -۷۱.۵۶%). Conclusion: The results of this study confirm the relationship between low levels of PAPP-A and adverse outcomes of pregnancy. In the present study, the optimal cut-off point (۰.۷۳) is higher than other studies, which can be due to racial and epidemiological differences.