Blowfly Larvae Recognize where they Are (Wound or Corpse)?

BACKGROUND AND OBJECTIVESA number of dangerous bacteria such as E.coli , MRSA, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis and some other bacteria are active in the wound and due to the many reasons, in chronic wounds the human immune system is not responsive and infection in the wound cause limb amputation or death of the patient! But fortunately, the larvae of blowfly very quickly destroys the biofilm that exists in all chronic wounds, and cures osteomyelitis in a very short period of time. During maggot therapy it is observed that the ESR and CRP of the patient decreased every day! In chronic wounds, where pathogenic bacteria are very active, the microbial toxins cause great damage to the tissues in the wound, but as soon as the larvae are placed in the wound, caused destroying microbes and microbial toxins. It is necessary for the larvae to destroy microbes, microbial toxins, biofilm formed in the wound, dead and necrotic tissues, and secrete growth factors to heal the wound. Fortunately, one of the important character of the larvae is that they recognize where they are working! In corpse they have the maximum secretion of proteolytic enzyme, and the secretion of this enzyme in the wound is regulated. It is necessary that the larvae heal the wound, but do not cause any damage to the healthy parts of the wound. If the larvae have the maximum secretion of proteolytic enzyme in the wound, it will cause the wound to enlarge and larvae will never be able to heal the wound. Fortunately, when the larvae are active in the corpse, they have the maximum secretion of proteolytic enzyme, and when they are active in the wound, the secretion of the proteolytic enzyme is regulated.MATERIALS AND METHODSIn laboratory, as soon the technician provide a piece of meat to the larvae, meat turns into a soap very quickly. By secreting a proteolytic enzyme, the larvae turn dead and necrotic tissues into soap. Larvae are not able to chew food, and it is necessary to turn the dead and necrotic tissues into a soapy form and then sucking this soapy food.RESULTS AND DISCUSSIONFortunately, as soon as granulation tissue appears in the wound, the larvae leave the wound, and when the larvae leave the wound, they die because food is not available to them. In other words, the larvae prefer death to damage the granulation tissue.CONCLUSIONLarvae not only recognize where there are(in wound or corpse)?But, also larvae easily recognize black, yellow and pink wounds, and the level of proteolytic enzyme secreted by the blowfly larvae is different in black, yellow and pink wounds. The black wound is the most dangerous wound, so the level of proteolytic enzyme secretion by the blowfly larvae is higher in black wound than in the yellow and pink wounds, also the level of proteolytic enzyme secretion is higher in the first days of inflammation phase of a chronic wound than in the end stage of inflammation phase. Fortunately, the blowfly larvae can regulate the level of proteolytic enzyme secretion, and when the larvae works on the dead body of any mammals, birds, reptiles and all other creatures, the secretion of proteolytic enzyme will be more than black wounds.