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مقالات فارسیISIکنفرانسهاژورنالها

Aspirin administration from early pregnancy versus initiation after ۱۱ weeks of gestation for prevention of pre-eclampsia in high-risk pregnant women: Study protocol for randomized controlled trial

محل انتشار: مجله طب تولید مثل ایران، دوره: 22، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 55

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لینک ثابت به این مقاله:
https://civilica.com/doc/1923163

شناسه ملی سند علمی:

JR_IJRM-22-1_008

تاریخ نمایه سازی: 7 اسفند 1402

چکیده مقاله:

Background: Pre-eclampsia (PE) is a multiorgan disorder that affects ۲-۵% of all pregnant women. Present recommendations for when to start aspirin in high-risk women are after ۱۱ wk of gestation. Objective: We present a protocol to investigate the effectiveness of aspirin use from early pregnancy, which is a randomized controlled trial to assess whether prescribed low-dose aspirin from early pregnancy reduces the prevalence of early and late-onset PE. Additionally, to compare the effectiveness of aspirin administration before and after ۱۱ wk in reducing the occurrence of PE? Materials and Methods: All pregnancies at risk of PE, according to demographic and midwifery history, who are referred to the Maternal-Fetal Clinic of Tehran University hospital, Tehran, Iran were invited to take part in the trial. The outcomes of pregnancy and newborns will be gathered and analyzed. The first registration for the pilot study was in January ۲۰۲۳, and the participants were recognized as high-risk for PE. In addition, enrollment in the main study will begin as of October ۲۰۲۳.

کلیدواژه ها:

Pre-eclampsia ، Aspirin ، Color doppler ultrasonography ، Pregnancy ، First trimester ، Pregnancy-associated plasma protein-A. ، پره اکلامپسی ، آسپرین ، سونوگرافی داپلر رنگی ، بارداری ، سه ماهه اول ، پروتئین پلاسمای مرتبط با بارداری-A.

نویسندگان

Sedigheh Hantoushzadeh

Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Arezoo Behzadian

Department of Perinatology, Vali-E-Asr Hospital, Imam Khomeini Hospital Complex, Tehran, Iran.

Mohammad Mehdi Hasheminejad

Iran University of Medical Sciences, Tehran, Iran.

Faezeh Hasheminejad

Asklepios Psychiatry Lower Saxony GmbH, Asklepios Specialist Clinic, Gottingen, Germany.

Alireza Helal Birjandi

Hannover Medical School, Clinic for Urology, Hannover, Germany.

Mojtaba Akbari

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medicine Sciences, Isfahan, Iran.

Marjan Ghaemi

Vali-E-Asr Hospital, Imam Khomeini Hospital Complex, Iran.

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