Biosynthesis of highly stabilized silver nanoparticles by Rhizopus stolonifer and their Anti-fungal efficacy

Highly stabilized monodispersed silver nanoparticles (AgNPs) were synthesized by Rhizopus stolonifer and the antifungal efficacy of silver nanoparticles (AgNPs) against Candida sp. were studied. Characterization of biosynthesized nanosilver was made by TEM-EDS and AFM. Minimum Inhibitory Concentration (MIC) of biosynthesized AgNPs, Amphotericin B, and Fluconazole have been studied on pathogenic fungi and the changes on membrane reactions have been elucidated by Scanning Electron Microscopy (SEM). The present study indicates AgNPs has considerable antifungal activity comparison with other antifungal drugs Nanosilver showed potent activity against pathogenic fungi.  The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have effective antifungal activity, deserves further investigation for clinical applications.