Unraveling the Potential of hsa-miR-۵۹۲ as a Key Player in Colorectal Cancer Management

Introduction: Colorectal Cancer (CRC) stands as a significant global health challenge, compellingly warrantingcomprehensive exploration. MicroRNAs (miRNAs), concise non-coding RNAs of roughly ۲۲ nucleotides inlength, transcribed from non-protein coding genes or introns, intricately modulate gene expression, holdingpivotal relevance in the molecular landscape of CRC. The intricate dysregulation and multifaceted roles ofmiRNAs have been implicated in driving critical processes such as carcinogenesis, tumor growth, and metastasisin the context of CRC. Within this expansive landscape, miR-۵۹۲ has prominently emerged as a potentialinfluential factor across a spectrum of cancer types. Consequently, this comprehensive review endeavors tounravel the profound impact and multifaceted role of miR-۵۹۲ in the context of CRC, shedding light on itsexpression patterns and clinical prognosis.Search Method: In this systematic review, a search strategy employing the keywords “hsa-miR-۵۹۲,” “mir-۵۹۲,” and “colorectal cancer” was executed, yielding ۱۲, ۳, and ۳۱ articles from the PubMed, Web of Science(WOS), and Scopus databases, respectively. The application of the PRISMA guideline facilitated theimplementation of inclusion and exclusion criteria, ultimately resulting in the inclusion of ۵ articles for thestudy.Conclusion: Substantial overexpression of miR-۵۹۲ was detected in colorectal carcinogenic (CRC) tissues andcell lines when compared to their corresponding non-malignant neighboring tissues and normal colon cells. Inthe context of CRC, serum, and tissues exhibiting increased miR-۵۹۲ levels demonstrated an association withdecreased patient overall survival. Investigations into cellular phenotypes revealed that miR-۵۹۲ promotes theproliferation, migration, and invasiveness of CRC cell populations. Alternatively, the novel targets of miR-۵۹۲include Forkhead Box O۳A (FoxO۳A) and the secreted protein acidic and rich in cysteine (SPARC). Thefindings provide evidence for a contributory role of miR-۵۹۲ in the promotion of CRC progression andmetastasis, potentially through its interaction with FoxO۳A and SPARC. In summary, this comprehensivereview establishes miR-۵۹۲ as a significant contributor to colorectal cancer progression. Its diverse effects oncell behavior and signaling pathways underscore its potential as a promising therapeutic target for thismalignancy.