The effect of salvia in decreasing depression and anxiety

Introduction: Sage with the scientific name (salvia officinalis) is one of the most important species of the mintfamily. Most of the species of this genus have medicinal properties and have many uses in traditional medicine.This plant has anti-depressant, analgesic effects, and sage's antimicrobial and antioxidant properties have beennoted. The aim of the current study is to investigate the effects of sage on reducing depression and anxiety.Methods: The present study is a review study that was written in ۲۰۲۲. Medline/PubMed, Google Scholar, andWeb of Sciences databases were used to search for related articles. In the first stage, a total of ۳۲ articles werefound, after applying the entry and exit criteria, this number was reduced to ۱۴. The inclusion criteria included:the article being Latin and the availability of the full text, and the exclusion criteria included: case report studies.Results: Considering the anti-depressant effects of sage, this plant cures depression by increasing serotoninand at the same time decreasing cortisol. Also, the other effect of this plant is related to the release of dopamine,which makes a person feel good. In order to investigate the anti-depressant effects of sage, researchers injectedthe extract obtained from this plant with different concentrations into mice, for investigating the anti-depressanteffects of this plant they used the "forced swimming test" and "hanging the mouse by the tail test" and forinvestigating anti-anxiety behaviors used the "open field test" and the "elevated plus maze test".Conclusion: Due to its medicinal and therapeutic activities, sage can be used for drug development. In order totreat depression and anxiety, our goal is to produce drugs with greater efficacy and fewer side effects. In thisstudy anti-depression and anti-anxiety properties of the methanolic extract of the prickly sage plant were proven;However, more researches are needed for the clinical use of this plant.