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مقالات فارسیISIکنفرانسهاژورنالها

Alleviating sepsis: Revealing the protective role of costunolide in a cecal ligation and puncture rat model

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 27، شماره: 5
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 30

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لینک ثابت به این مقاله:
https://civilica.com/doc/1933445

شناسه ملی سند علمی:

JR_IJBMS-27-5_006

تاریخ نمایه سازی: 19 اسفند 1402

چکیده مقاله:

Objective(s): Sepsis poses a significant threat to human life, rendering it a burdensome medical disease. Despite significant advancements, the current state of medical science still lacks a viable and efficacious cure. Costunolide (COST) is a multifaceted sesquiterpene lactone that exhibits a range of actions, including anti-inflammatory and antioxidant properties. We investigated the potential impacts of COST on a rat sepsis model caused by cecal ligation and puncture (CLP).Materials and Methods: We created an experimental rat model with the following groups: SHAM, CLP, CLP+low dose COST, and CLP+high dose COST. Blood, kidney, and lung samples were collected. Inflammatory mediators such as interleukin-۱beta (IL-۱β), IL-۶, tumor necrosis factor-alpha (TNF- α), and nuclear factor kappa-B (NF-κB) were investigated. In addition, we assessed oxidative stress by measuring ۸-Hydroxydeoxyguanosine (۸-OHdG) immunopositivity, MDA levels, glutathione (GSH), and superoxide dismutase (SOD) activity. Histopathological and immunohistochemical examinations backed up our findings.Results: Compared to the CLP group, the COST group showed a reduction in inflammatory and oxidative stress indicators. The expression of inflammatory mediators was suppressed by COST, and histological examinations revealed improvements in kidney and lung tissues in the treatment groups.Conclusion: Our study highlights the preventive effects of COST against CLP-induced sepsis-related injury. Considering its beneficial effects against many diseases, COST is worthy as to be evaluated against sepsis.

کلیدواژه ها:

Cecal ligation and puncture ، Costunolide ، Oxidative stress ، Rat ، Sepsis

نویسندگان

Mustafa Güler

Department of Physiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey

Ayhan Tanyeli

Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey

Ersen Eraslan

Department of Physiology, Faculty of Medicine, Bandırma OnYedi Eylül University, Balıkesir, Turkey

Özgür Çelebi

Department of Medical Microbiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey

Demet Çelebi

Department of Microbiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey

Selim Çomakli

Department of Pathology, Faculty of Veterinary, Atatürk University, Erzurum, Turkey

Emir Yurdgülü

Department of Biochemistry, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey

Yasin Bayir

Department of Biochemistry, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey

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