The Relationship between Chronic Urticaria and Helicobacter pylori Infection

Chronic urticaria is a prolonged disease with unknown etiology and management.in order to determine the association of helicobacter pylori(H.pylori) infection with chronic urticaria,a case-control study was carried out in this regard ۹۵ chronic urticaria patients without any underlying etiology and ۱۹۰ healthy individuals who were matched for age and sex were evaluated by-anti-H.pylori IgG detection.in patients groupe ۶۸(۴۱.۶%) were female,۲۷(۲۸.۴%)male,and in control group ۱۳۶ were female and ۵۴ male.the mean age of paatients group was ۳۲.۴+_۱۵.۷ years and in control group it was ۳۱.۹+_۱۴.۸ years(p>۰.۰۵).the average duration for chronic urticaria was ۲۲.۷ months.Among other findings in patients group were asthma (۱۳.۷%).allergic rhinitis (۱۶.۸%),angioedema(۴۳.۲%) and gastrointestinal (GI)complaints (۳۲.۱%).anti-H.pylori antibody was detected in ۷۱(۷۴.۷%) of patients and in ۹۶(۵۰.۵%) of healthy persons with a significant difference (p<۰.۰۰۱).there was a significant difference for H.pylori infection in ۲۰-۵۰ years age class in patients group (p<۰.۰۱),but the relation between duration of urticaria,angioedema,and Gl complaints with H.pylori infection wa nonsignificant (p>۰.۰۵).according to these results H.pylori infection is more frequent in chronic idiopathic urticaria patients than in healthy subjects.however to clarify its etiopathogenesis it is essential to implement more basic research and therapeutic trials.