A report of two cases of sarcoidosis in a family(brother and sister):case report

sarcoidosis is a granulomatius disease of unknown etiology involving multiple body systems.approximately ۱۰-۳۵% of patients with systemic disease have cutaneous involvement.skin lesions commonly observed in sarcoidosis include:erythema nodosum,macular or parpular rashes,nodules,hypopigmented or hyperpigmented patches,scarsarcoid,lupus pernio,plaques,and rarely mocusal lesions.this report describes two cases of sarcoidosis in a sister and brother(familial sarcoidosis),who developed sarcoidal skin skin lesions  like macules,papules,plaques,nodules,lupus pernio,accompanied whit lung involvement and enlargement of submandibular glands.buccal mucusa and tongue invilvement were seen only in the sister,while parotid glands enlargement and generalized lymphadenopathy was detected only in the brother.the occurrence of sarcoidosis in more than one member of a family is uncommon but well recognized.sarcoidosis is a rare disorder in Iran and till now familial sarcoidosis has notbeen reported in this country.the aim of presentation of this report is introduction of familial sarcoidosis which is a very rare disease.