Effect of pioglitazone, quercetin and hydroxy citric acid on extracellular matrix components in experimentally induced non-alcoholic steatohepatitis
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 18، شماره: 8
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 40
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شناسه ملی سند علمی:
JR_IJBMS-18-8_015
تاریخ نمایه سازی: 23 اسفند 1402
چکیده مقاله:
Objective(s):Non-alcoholic steatohepatitis (NASH), is an important component of Non-alcoholic fatty liver disease (NAFLD) spectrum, which progresses to the end stage liver disease, if not diagnosed and treated properly. The disproportionate production of pro- and anti-inflammatory adipokines secreted from fat contributes to the pathogenesis of NASH. In this study, the comparative effect of pioglitazone, quercetin and hydroxy citric acid on extracellular matrix (ECM) component levels were studied in experimentally induced NASH. Materials and Methods: The experimental protocol consists of using ۴۸ male Wister rats, which were divided into ۸ groups. The levels of hyaluronic acid, leptin and adiponectin were monitored in experimental NASH. Results:The experimental NASH rats treated with pioglitazone showed significant decrease in the levels of hyaluronic acid and significant increase in adiponectin levels when compared to experimentally induced NASH group, but did not show any effect on the levels of leptin. Contrary to these two drugs, viz. pioglitazone and hydroxy citric acid, the group treated with quercetin showedsignificant decrease in the levels of hyaluronic acid and leptin and significant decrease in adiponectin levels compared with that of experimentally induced NASH NASH group, offering maximum protection against NASH. Conclusion: Considering our findings, it could be concluded that quercetin may offer maximum protection against NASH by significantly increasing the levels of adiponectin, when compared to pioglitazone and hydroxy citric acid.
کلیدواژه ها:
Adiponectin ، Hyaluronic acid ، Hydroxy citric acid ، Leptin ، Non-alcoholic fatty liver – disease (NAFLD) ، Non-alcoholic–steatohepatitis (NASH) ، Pioglitazone ، Quercetin
نویسندگان
Surapaneni Krishna Mohan
Department of Biochemistry, Saveetha Medical College and Hospital, Faculty of Medicine, Saveetha University, Saveetha Nagar, Thandalam, Chennai – ۶۰۲ ۱۰۵, Tamilnadu, India
Vishnu Priya Veeraraghavan
Department of Biochemistry, Saveetha Dental College and Hospital, Saveetha University, ۱۶۲, P.H.Road, Chennai – ۶۰۰ ۰۷۷, Tamilnadu, India
Mallika Jainu
Department of Biomedical Engineering, SSN Engineering College, OMR, Klavakkam, Chennai – ۶۰۳ ۱۱۰, Tamilnadu, India
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