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مقالات فارسیISIکنفرانسهاژورنالها

Sphingosine ۱-phosphate interacts with Survivin pathway to enhance tumorigenesis in cancer cells

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 18، شماره: 8
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 31

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لینک ثابت به این مقاله:
https://civilica.com/doc/1938950

شناسه ملی سند علمی:

JR_IJBMS-18-8_012

تاریخ نمایه سازی: 23 اسفند 1402

چکیده مقاله:

Objective(s):Degradation of sphingosine ۱-phosphate (S۱P), as a bioactive lipid, or deregulation of its production involves in tumor progression, metastasis and chemoresistance. Since the tumor progression effects of S۱P and its mechanism in chronic lymphoblastic leukemia and non-small cell lung cancer is not fully understood, we investigated the role and one of the mechanisms of S۱P in tumor progression of SKW۳ and H۱۲۹۹ cells. Materials and Methods: The effects of S۱P on proliferation, invasion and migration was studied using MTT assay, soft-agar colony forming assay and trans-well migration assay, respectively. In order to find out the mechanisms of S۱P action, the role of S۱P on expression of Survivin gene was assessed by real-time RT-PCR. Results:Our results demonstrated that although invasion was shown only in H۱۲۹۹ cells, low concentration of S۱P, especially at ۱ μM, mediated proliferation and migration in both cell lines. In addition, these effects of S۱P in tumor progression are S۱P receptor-dependent, and Survivin plays a key role in S۱P tumorigenesis. Conclusion:Our results confirmed the involvement of S۱P and its receptors in tumor progression of SKW۳ and H۱۲۹۹. We also investigated another mechanism of S۱P involved in cell survival, tumor progression, and Survivin signaling. In conclusion, data demonstrated the importance of this molecule as a target for designing new anticancer drugs such as anti-S۱P monoclonal antibody for inhibiting major downstream signaling, which plays significant role in tumorigenesis.

کلیدواژه ها:

Invasion ، Migration ، Proliferation ، Survivin ، S۱P

نویسندگان

Maryam Tabasinezhad

Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran Student Research

Hamid Ghaedi

Medical Genetics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Parisa Qanbari

Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Mahsa Mohseni

Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Mehdi Sabzichi

Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Nasser Samadi

Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

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