Chlorpyrifos-induced testicular damage in rats: The effect of glutathione antioxidant
محل انتشار: مجله علمی پیشرفت های دامپزشکی، دوره: 2، شماره: 7
سال انتشار: 1392
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 38
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شناسه ملی سند علمی:
JR_SJVA-2-7_001
تاریخ نمایه سازی: 24 اسفند 1402
چکیده مقاله:
This study investigated the induction of oxidative stress in the testis of adult rat exposed to Chlorpyriphos (CPF). CPF was administered orally, in a dose of ۳۰ mg/kg body weight to male rats for ۹۰ days/ twice/ weekly. Co- administration of water soluble non enzymatic antioxidant glutathione (GSH) was given in a dose of ۱۰۰ mg/kg body weight, oral, for the same period. Another two groups of male rats were administered GSH and corn oil, respectively. The activities of superoxide dismutase and glutathione reductase were decreased while the levels of lipid peroxidation were increased in the testicular tissues of the exposed animals. Testosterone hormone level in the serum was significantly decreased. The decrease in the histochemical determination of testicular alkaline phosphatase was observed in CPF-treated rats. A significant decrease in all stages of spermatogenesis in the seminiferous tubules was recorded in the exposed animals. Co-dministration of GSH restored these parameters.This study investigated the induction of oxidative stress in the testis of adult rat exposed to Chlorpyriphos (CPF). CPF was administered orally, in a dose of ۳۰ mg/kg body weight to male rats for ۹۰ days/ twice/ weekly. Co- administration of water soluble non enzymatic antioxidant glutathione (GSH) was given in a dose of ۱۰۰ mg/kg body weight, oral, for the same period. Another two groups of male rats were administered GSH and corn oil, respectively. The activities of superoxide dismutase and glutathione reductase were decreased while the levels of lipid peroxidation were increased in the testicular tissues of the exposed animals. Testosterone hormone level in the serum was significantly decreased. The decrease in the histochemical determination of testicular alkaline phosphatase was observed in CPF-treated rats. A significant decrease in all stages of spermatogenesis in the seminiferous tubules was recorded in the exposed animals. Co-dministration of GSH restored these parameters.
کلیدواژه ها:
نویسندگان
E. E. Elsharkawy
Departement of Fronsic Med. And Toxicology Fac. Vet .MED. Assuit University, Egypt
D. Yahia
Departement of Fronsic Med. And Toxicology Fac. Vet .MED. Assuit University, Egypt
N.A. El-Nisr
Animal Health Institute of Research- Egypt
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