Determination of ficolin-۲ levels and its relationship with age in patients with osteoarthritis(OA)

Introduction: this study aims to investigate the levels of ficolin-۲ in patients with OA and explore its relationship with age. By elucidating the potential role of ficolin-۲ in OA pathophysiology and its association with age-related changes, this study may contribute to our understanding of the inflammatory mechanisms underlying OA.Material and Methods: Ficolin-۲ levels were quantified using a dedicated human ficolin-۲ enzyme-linked immunosorbent assay (ELISA) kit. The assay followed the manufacturer's instructions with duplicate measurements for each sample. Standard curves were generated using known concentrations of ficolin-۲, and sample concentrations were interpolated accordingly.Results: Ficolin-۲ levels were measured in each participant, revealing a distribution that varied across different age groups. The analysis suggested a [۲۲/۶۳/۱۵] correlation between ficolin-۲ levels and age.Conclusion: this study has provided valuable insights into the relationship between ficolin-۲ levels and age in patients with osteoarthritis. The positive correlation observed suggests a potential role for ficolin-۲ in the age-related immune responses associated with osteoarthritis.