Predictive role of lactate in dogs with acute pancreatitis advanced to systemic inflammatory response syndrome
محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 15، شماره: 3
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 28
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شناسه ملی سند علمی:
JR_VRFAN-15-3_001
تاریخ نمایه سازی: 28 اسفند 1402
چکیده مقاله:
Acute pancreatitis (AP) can develop into life-threatening conditions such as systemic inflammatory response syndrome (SIRS) or multiple organ dysfunction syndrome. Thirty-nine of ۵۴ client-owned dogs admitted to the Referral Animal Medical Center and diagnosed with AP within ۲۴ hr of onset were retrospectively reviewed to assess early predictors of progression from AP to SIRS. The patients were divided into SIRS (SIRS occurring after AP) and non-SIRS (AP occurring but no SIRS) groups. The population and mean values of laboratory variables within ۲۴ hr of admission were assessed and compared between both groups. There were significantly more dogs with abnormal lactate levels in the SIRS group (۸۰.۰۰%) than non-SIRS group (۱۱.۱۰%). Other parameters did not differ significantly. Mean lactate level values were significantly higher at ۳.۶۴ ± ۱.۷۵ mmol in the SIRS group compared to ۱.۶۸ ± ۰.۵۲ mmol in the non-SIRS group. The increased energy required by activated immune cells may lead to metabolic changes characterized by anaerobic glycolysis and increased lactate production. This study’s results suggest blood lactate monitoring in the early stages of progression from AP to SIRS in small animal clinical practice. Measuring lactate levels at the early stages of pancreatitis could lead to rapid therapeutic intervention for SIRS and ultimately reduce mortality.
کلیدواژه ها:
acute pancreatitis ، Dog ، Lactate ، specific canine pancreatic lipase ، Systemic inflammatory response syndrome
نویسندگان
Sei-Myoung Han
Department of Animal Health and Welfare, College of Health and Biotechnology, Semyung University, Jecheon, South Korea
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