Impact of Dose Calculation Algorithms and Radiobiological Parameters on Prediction of Cardiopulmonary Complications in Left Breast Radiation Therapy
محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 14، شماره: 2
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 29
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شناسه ملی سند علمی:
JR_JBPE-14-2_003
تاریخ نمایه سازی: 18 فروردین 1403
چکیده مقاله:
Background: Breast cancer requires evaluating treatment plans using dosimetric and biological parameters. Considering radiation dose distribution and tissue response, healthcare professionals can optimize treatment plans for better outcomes. Objective: This study aimed to evaluate the effects of the different Dose Calculation Algorithms (DCAs) and Biologically Model-Related Parameters (BMRPs) on the prediction of cardiopulmonary complications due to left breast radiotherapy. Material and Methods: In this practical study, the treatment plans of ۲۱ female patients were simulated in the Monaco Treatment Planning System (TPS) with a prescribed dose of ۵۰ Gy in ۲۵ fractions. Dose distribution was extracted using the three DCAs [Pencil Beam (PB), Collapsed Cone (CC), and Monte Carlo (MC)]. Cardiopulmonary complications were predicted by Normal Tissue Complication Probability (NTCP) calculations using different dosimetric and biological parameters. The Lyman-Kutcher-Burman (LKB) and Relative-Seriality (RS) models were used to calculate NTCP. The endpoint for NTCP calculation was pneumonitis, pericarditis, and late cardiac mortality. The ANOVA test was used for statistical analysis. Results: In calculating Tumor Control Probability (TCP), a statistically significant difference was observed between the results of DCAs in the Poisson model. The PB algorithm estimated NTCP as less than others for all Pneumonia BMRPs. Conclusion: The impact of DCAs and BMRPs differs in the estimation of TCP and NTCP. DCAs have a stronger influence on TCP calculation, providing more effective results. On the other hand, BMRPs are more effective in estimating NTCP. Consequently, parameters for radiobiological indices should be cautiously used s to ensure the appropriate consideration of both DCAs and BMRPs.
کلیدواژه ها:
Breast neoplasms ، Radiotherapy ، Tumor Control Probability ، Normal Tissue Complications Probability ، Dose Calculation Algorithm ، Models ، Biological
نویسندگان
Niloofar Kargar
Department of Medical Physics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Ahad Zeinali
Department of Medical Physics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Mikaeil Molazadeh
Department of Medical Physics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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