Correlation between the Suitability of Empirical Antibiotic Therapy and Culture Results on Clinical Outcomes of Pneumonia Patients at Dr. Soetomo Regional Public Hospital, Surabaya
محل انتشار: مجله علوم دارویی و شیمی، دوره: 7، شماره: 5
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 29
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شناسه ملی سند علمی:
JR_JMCH-7-5_002
تاریخ نمایه سازی: 18 فروردین 1403
چکیده مقاله:
Pneumonia is a global health concern, causing significant morbidity and mortality, particularly among vulnerable populations. This study, conducted at Dr. Soetomo Regional Public Hospital (RSUD Dr. Soetomo), Surabaya, Indonesia, aimed to assess the causative pathogens, antibiotic sensitivity patterns, and the impact of empiric therapy on the clinical outcomes of pneumonia patients. The present study analyzed ۳۲۴ cases from January to March ۲۰۲۳, categorizing pneumonia as community-acquired (CAP), hospital-acquired (HAP), and ventilator-associated (VAP). Gram-negative bacteria, predominantly Klebsiella pneumoniae, were the primary pathogens, with ۴۴% being multidrug-resistant. Antibiotic sensitivity patterns highlighted the efficacy of amikacin, cefoperazone sulbactam, and meropenem against Gram-negative bacteria. Empiric therapy, mainly monotherapy, showed varied outcomes across pneumonia types. Clinical improvement was observed in ۷۲.۵% of CAP patients, while HAP and VAP patients faced challenges, with high mortality rates of ۴۷.۲% and ۸۹.۱%, respectively. Clinical stability in CAP correlated with age, culture results, multidrug resistance, pneumonia severity, and antibiotic class. In HAP, appropriate empiric therapy and pneumonia severity influenced clinical outcomes. Notably, VAP patients experienced poor outcomes irrespective of the variables studied. This study underscores the importance of local pathogen prevalence awareness and tailored empiric therapy to enhance pneumonia management, especially in HAP and VAP cases. Further research is warranted to refine treatment strategies and improve patient outcomes.
کلیدواژه ها:
نویسندگان
Suharyadi Sasmanto
Study Program of Clinical Microbiology Specialist, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Pepy Dwi Endraswari
Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
SR Oktaviani Sulikah
Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Ni Made Mertaniasih
Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Tutik Kusmiati
Dr. Soetomo Academic Hospital, Surabaya, Indonesia
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