The Effect of High Intensity Interval Training on Lipocalin ۲ Gene Expression in Subcutaneous Adipose Tissue and Insulin Function in Obese Rats with Induced Diabetes
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 35
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شناسه ملی سند علمی:
JR_JNFH-12-2_002
تاریخ نمایه سازی: 19 فروردین 1403
چکیده مقاله:
Introduction: Genetic evidence indicates the key role of transcription factors on insulin signaling pathways. The present study was performed with the aim of assess the effect of high intensity interval training (HIIT) on gene lipocalin-۲ (LCP۲) gene expression in subcutaneous adipose tissue, insulin resistance and glucose in obese rats with type ۲ diabetic (T۲D). Methods: For this purpose, ۲۱ male Wistar rats aged ۱۰ weeks of old were obesed by ۸ weeks high-fat diet (HFD) and then ۱۴ rats became T۲D by STZ injection (۲۵ mg/dL). The rats were divided into obese, control diabetic and HIIT diabetic groups. HIIT group participated in ۸-week HIIT (۵ sessions/weekly), and the control groups did not participate in the exercise program. ۴۸ hours after the last training session, glucose and insulin resistance and gene LCN۲ expression in subcutaneous adipose tissue were measured and compared by one-way ANOVA test. Results: Type ۲ diabetes induction led to an increase in glucose and insulin resistance (P=۰.۰۰۱) as well as an increase in the expression of LCN۲ (P=۰.۰۰۱) compared to the obese group. In other words, HIIT led to a significant decrease in glucose, insulin resistance (P=۰.۰۰۱) as well as a significant decrease in LCN۲ expression (P=۰.۰۰۲) in subcutaneous adipose tissue compared to the diabetic control group. Conclusion: HIIT is associated with improvement of insulin resistance and glycemic profile in diabetic rats, and this can be imputed to the increase in LCN۲ expression in subcutaneous adipose tissue in response to HIIT.
کلیدواژه ها:
نویسندگان
Mohsen Ahmady
Ph.D Student of Exercise Physiology, Islamic Azad University, Islamshahr Branch, Tehran, Iran.
Yaser Kazemzadeh
Assistant Professor of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Tehran, Iran.
Sanaz Mirzayan Shanjani Sanaz
Assistant Professor of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Tehran, Iran.
Mojtaba Eizadi
Assistant Professor of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran.
Valiollah Shahedy
Assistant Professor, Department of Physical Education and Sports Sciences, Parand Branch, Islamic Azad University, Tehran, Iran.
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