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مقالات فارسیISIکنفرانسهاژورنالها

Hypoglycemic and Antioxidants Activities of Carica Papaya Leaves

محل انتشار: مجله بین المللی تحقیقات پیشرفته زیست شناختی و زیست پزشکی، دوره: 12، شماره: 2
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 25

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لینک ثابت به این مقاله:
https://civilica.com/doc/1954337

شناسه ملی سند علمی:

JR_IJABBR-12-2_003

تاریخ نمایه سازی: 25 فروردین 1403

چکیده مقاله:

The objective of the current study was to assess the ethanolic and methanolic extracts of Carica papaya's hypoglycemic effects. Yeast glucose uptake, muscle glucose uptake, and glucose adsorption capacity were used to measure the extracts' in vitro hypoglycemic effects. The antioxidant capacity of the extracts was assessed by investigating how they affect lipid peroxidation brought on by iron (II) sulphate and sodium nitroprusside. The findings showed that glucose was absorbed by both the ethanolic and methanolic extracts of Carica papaya, and that this adsorption significantly increased as the concentration of glucose rose. There were no variations in their adsorption capabilities that were statistically significant (p=۰.۰۵). The yeast cells were also stimulated to take up glucose by the plant extracts, and this stimulation was influenced by the sample and glucose content. In the study's muscle glucose uptake, the ethanolic extract of Carica papaya leaves showed substantially greater (p=۰.۰۵) performance than the methanolic of the same leaves with increasing concentration. The study's findings showed that the plant's methanolic extract was substantially more potent than its ethanolic (p=۰.۰۵). In addition, the methanolic extract considerably inhibited the generation of MDA (malondialdehyde) in the liver and brain homogenates more than the ethanolic extract did. Both plant extracts also exhibit dose-dependent inhibition of the various pro-oxidant agents (Iron (II) Sulphate and sodium nitroprusside) caused fatty acid oxidation tissues present in the brain and liver.

کلیدواژه ها:

Carica papaya ، Hypoglycemic ، Antioxidant Activity ، Lipid peroxidation ، malondialdehyde

نویسندگان

Olumakinde Charles Omiyale

Department of Pharmacology, Toxicology and Therapeutics, College of Medicine, University of Lagos, ۱۰۱۰۱۴, Nigeria

Blessing Ifeoluwa Ogunniran

Department of Environmental Science, School of Environment, Northeast Normal University, ۱۳۰۰۲۴, China

Mercy Ogochukwu Ezeh

Department of Plant Breeding, Crop Improvement Unit, Cocoa Research Institute of Nigeria (CRIN), Nigeria

Mubaraq Damilare Yussuf

Department of Biochemistry, Faculty of Life Sciences, Lagos State University, Lagos, ۱۰۲۱۰۱, Nigeria

Confidence Damian Oparah

Department of Internal Medicine, National Hospital Abuja, Abuja, ۹۰۰۲۱۱, Nigeria

Fawaz Isshak

Department of Horticulture, Faculty of Agriculture and Natural Resources, Kwame Nkrumah University of Science and Technology, Ghana

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