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مقالات فارسیISIکنفرانسهاژورنالها

Urtica pilulifera L. seed extract promotes folliculogenesis and alleviates the diminished ovarian reserve in the Balb/c mice model: An experimental study

محل انتشار: International Journal of Reproductive BioMedicine، دوره: 22، شماره: 2
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 35

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لینک ثابت به این مقاله:
https://civilica.com/doc/1954381

شناسه ملی سند علمی:

JR_IJRM-22-2_003

تاریخ نمایه سازی: 25 فروردین 1403

چکیده مقاله:

Background: Urtica pilulifera L. seed (UPS) is a Persian traditional medicine prescription that positively affects female infertility. Objective: This study aimed to evaluate the beneficial effects of UPS on a diminished ovarian reserve (DOR) model induced by cyclophosphamide in Balb/c mice. Materials and Methods: A single intraperitoneal (۷۵ mg/kg) of cyclophosphamide was administered to establish a DOR model. ۲۵ female Balb/c mice (۶-۸ wk, ۲۵ ± ۲ gr) were randomly divided into ۵ groups (n = ۵/each), including control (normal saline), model (DOR), DOR+۵۰, DOR+۱۰۰, and DOR+۲۰۰ (mg/kg UPS, gavage) groups for ۱۴ days. The levels of follicle-stimulating hormone, luteinizing hormone, estradiol, malondialdehyde, superoxide dismutases, apoptosis, and histopathological alterations were analyzed. Gas chromatography-mass spectrometry analysis performed to identify the phytochemicals of the UPS. Results: It was observed that the UPS extract reduced malondialdehyde concentration and apoptosis in the DOR model as well as enhanced superoxide dismutases activity in the ovaries in a dose-dependent manner. Moreover, it exerted a modulatory effect on steroidal hormones such as follicle-stimulating hormone, luteinizing hormone, and estradiol. The histopathological analysis revealed the therapeutic potential of the UPS extract. The main chemical components of UPS were linoleic acid (۵۹.۲۵%), n-hexadecanoic acid (۱۰.۳۶%), and oleic acid (۸.۲۹%). Conclusion: The results indicated that the UPS extract has therapeutic potential in the DOR model. This potential is attributed to the reduction of oxidative stress, modulation of apoptosis, and regulation of steroidal hormones that may be associated with the observed beneficial effects of fatty acids on fertility improvement

کلیدواژه ها:

Apoptosis ، Fatty acids ، Female infertility ، Herbal medicine ، Persian medicine ، Oxidative stress. ، آپوپتوز ، اسیدهای چرب ، ناباروری زنان ، داروهای گیاهی ، طب ایرانی ، استرس اکسیداتیو.

نویسندگان

Sharareh Hekmat

Department of Traditional Pharmacy, School of Traditional Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Sharifzadeh

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Tayebeh Toliyat

Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Roghayeh Savary Kouzehkonan

Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mozhgan Mehri Ardestani

Department of Persian Medicine, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.

Malihe Tabarrai

Department of Persian Medicine, School of Traditional Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Seyede Nargess Sadati Lamardi

Department of Traditional Pharmacy, School of Traditional Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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