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مقالات فارسیISIکنفرانسهاژورنالها

Epidemiological Study of Hepatitis D Virus in HBsAg Positive Patients in Khorramabad City, West of Iran, ۲۰۱۹

محل انتشار: فصلنامه میکروب شناسی پزشکی ایران، دوره: 18، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 28

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لینک ثابت به این مقاله:
https://civilica.com/doc/1955902

شناسه ملی سند علمی:

JR_IJMM-18-1_001

تاریخ نمایه سازی: 27 فروردین 1403

چکیده مقاله:

Introduction & Objective: Co-infection of HBV and HDV leads to more severe hepatitis, with a higher risk of acute liver failure and hepatocellular carcinoma (HCC). This study aimed to assess the prevalence of HDV in HBsAg-positive patients in Khorramabad, which has not been previously evaluated. Methods: A total of ۲۰۰ patients who tested positive for HBsAg were included in this study. Venous blood samples were collected in EDTA-free tubes. An ELISA test was performed to detect antibodies against HDV, and positive samples were further confirmed using RT-PCR. Population data were analyzed using SPSS software, and a P value ≤۰.۰۵ was considered statistically significant for all tests. Results: Out of the total participants, there were ۱۱۹(۵۹.۵%) men and ۸۱(۴۰.۵%) women. The age of the patients varied from ۵ to ۸۹ years, with an average age of ۴۹.۶۶ years. The HDV ELISA test was performed on HBsAg-positive individuals, yielding positive results for ۳۷(۱۸.۵%) patients. Additionally, ۱۰(۵%) patients showed borderline infection. The HDV RT-PCR results indicated that ۴۲(۲۱%) individuals tested positive. The prevalence of HDV showed a statistically significant difference between urban and rural areas with respect to molecular RT-PCR testing (P=۰.۰۳۲). Additionally, women, married individuals, and drug addicts were found to be at a higher risk of HDV infection. Conclusion: There is a high prevalence of HDV infection among patients who test positive for HBsAg in Khorramabad. Therefore, assessing the prevalence of HDV in HBsAg positive patients can aid in ensuring timely diagnosis and appropriate treatment for these individuals.

کلیدواژه ها:

HBV ، HDV ، HBsAg ، Prevalence ، Co-infection

نویسندگان

Negar Ghorbani

Hepatitis Research Center, Department of Virology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Ashkan Alamdary

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Sayyad Khanizadeh

Hepatitis Research Center, Department of Virology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Mehdi Birjandi

Department of Biostatistics and Epidemiology, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran

Mehdi Ajorloo

Hepatitis Research Center, Department of Virology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

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