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Evaluation of the Fluconazole Prophylaxis against Fungal Colonization in the Preterm Neonates: A Double-blind Clinical Trial

محل انتشار: مجله علمی ناباروری ایران، دوره: 15، شماره: 2
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 44

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1957818

شناسه ملی سند علمی:

JR_IRJN-15-2_003

تاریخ نمایه سازی: 28 فروردین 1403

چکیده مقاله:

Background: Our study aimed to compare the twice-weekly and three-time weekly prophylactic fluconazole regimens among low birth weight premature neonates. Methods: Premature neonates (۴۰ cases) were divided into two groups and received two and three-times-weekly fluconazole regimens for three weeks. Surveillance of fungal colonization was performed before treatment and twice weekly. Results: Fungal colonization occurred in ۱۱ infants in group A and ۴ infants in group B (۵۵% vs. ۲۰%, p=۰.۰۲۲). In both groups, the rectum was the most common site of colonization. Candida glabrata, Candida orthopsilosis and, Candida albicans were the most commonly isolated species in both groups. There were no significant differences between the two groups regarding birth weight, gestational age, and other baseline risk factors for fungal colonization. Conclusion: In this study, the three-times-weekly administration of prophylactic fluconazole appears to be more effective in preventing fungal colonization than the twice-weekly regimen among premature neonates.

کلیدواژه ها:

Candida ، Fluconazole ، Neonates

نویسندگان

Sara Amini

Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran

Gholamreza Pouladfar

۱. Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran ۲. Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Fatemeh Ghasemi

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Hadis Jafarian

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Parisa Badiee

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

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