ورود
مقالات فارسیISIکنفرانسهاژورنالها

Bioinformatic-based Study to Investigate the Structure and Function of Pro-inflammatory Cytokines TNFα and IL-۶ Involved in the Pathogenesis of COVID-۱۹

محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 19، شماره: 2
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 25

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1974006

شناسه ملی سند علمی:

JR_IJP-19-2_008

تاریخ نمایه سازی: 19 اردیبهشت 1403

چکیده مقاله:

Background & Objective: Besides the clinical and laboratory research on the COVID-۱۹ virus, the bioinformatics study in the field of genetics of immunity to COVID-۱۹ is of particular importance. In this account, studies show that in patients with COVID-۱۹, the level of tumor necrosis alpha (TNFα) and interleukin-۶ (IL-۶) is high and in severe cases of COVID-۱۹, the production of IL-۶, TNF-α, and other cytokines increases profoundly. On the other hand, investigating the molecular structure and receptors of IL-۶ and TNFα and the structural analysis of the receptor proteins may potentially help to develop new therapeutic plans for COVID-۱۹ infection.Methods: To identify genes with significant and different expressions in patients with COVID-۱۹ in a microarray data set containing transcriptional profiles from GEO as a functional genomic database the GEO query package version ۲.۶۴.۲ in a programming language R version ۴.۲.۱ was downloaded. In this way, functional enrichment analysis for DEGs, WikiPathways, REGO, gene ontology, and STRING database was also investigated and employed.Results: The structure and function of pro-inflammatory cytokines TNFα and IL-۶ involved in the pathogenesis of COVID-۱۹ were investigated, and in general, after performing various analyses in this study and extracting A series of genes with different expressions from the KEGG database, the final ۵ DEGs include CXCL۱۴, CXCL۶, CCL۸, CXCR۱, TNFRSF۱۰, and the relationship and expression effects of them were observed in different pathways.Conclusion: IL-۶ and TNFα were involved in immunological processes that had a direct and indirect relationship with the activation of cytokines, including IL۶ and TNF-a, and cytokine storm, and this indicates their role in the formation of problems and complications, including ARDS, in COVID-۱۹ patients. Of course, determining the effectiveness of each of these genes requires more specialized and clinical studies.

کلیدواژه ها:

Bioinformatics ، COVID-۱۹ ، Cytokine ، IL-۶ ، TNF-a

نویسندگان

Seyedeh Elham Norollahi

Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran

Kosar Babaei

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran

Vida Balooei

Department of Veterinary Medicine, Babol Branch, Islamic Azad University, Babol, Iran

Seyed Masoud Hashemi Karouei

Department of Veterinary Medicine, Babol Branch, Islamic Azad University, Babol, Iran

Mohammadtaghi Ashoobi

Department of Surgery, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran

Elahe Asghari Gharakhyli

Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran

Ali Akbar Samadani

Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran

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