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مقالات فارسیISIکنفرانسهاژورنالها

Analgesic Serotonin from Banana Fruit (Musa paradisiaca) on Serotonin ۱ b (۵-HT۱b) Receptor Protein In Silico

محل انتشار: فصلنامه شیمی آلی-فلزی کاربردی، دوره: 4، شماره: 2
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 35

فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد

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لینک ثابت به این مقاله:
https://civilica.com/doc/1977243

شناسه ملی سند علمی:

JR_JAOC-4-2_001

تاریخ نمایه سازی: 29 اردیبهشت 1403

چکیده مقاله:

Serotonin analgesics from banana (Musa paradisiaca) fruit have been investigated to determine potential interactions with serotonin ۱ b (۵-HT۱b) receptors at the molecular level. The study utilized an in silico approach to predict the interaction between serotonin analgesics and receptor proteins. The research method involved the use of Pymol, MOE ۲۰۱۵, Discovery Studio, and Lipinski Rule software. The use of Pymol and MOE was used for visualization of the molecular structures of serotonin analgesics and receptor proteins. Discovery Studio was used to analyze the interaction between serotonin analgesic and receptor protein, which revealed the presence of binding between the two with Binding Affinity of -۵.۱۲۹۷ and -۱۱.۱۰۶۱ and RMSD of ۱.۷۳۷۳ and ۳.۷۰۵۷. In addition, analysis by Lipinski Rule revealed the molecular characteristics of the serotonin analgesic, including a mass of ۱۹۶, no hydrogen bond donor, two hydrogen bond acceptors, a log P of ۳.۰۲۳, and a molar reactivity of ۵۶.۳۹۰. These results demonstrate the analgesic potential of serotonin in interacting with serotonin ۱ b (۵-HT۱b) receptors, which may form the basis for further research in drug development related to serotonin-based pain treatment.

کلیدواژه ها:

Serotonin analgesic ، Banana fruit (Musa paradisiaca) ، Serotonin ۱ b (۵-HT۱b) receptor protein ، Molecular interaction ، In silico approach

نویسندگان

Rahadian Zainul

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, West Sumatra, Indonesia

Herland Satriawan

Institute of Ocean and Earth Sciences, University of Malaya, ۵۰۶۰۳, Kuala Lumpur, Malaysia

Dheo Shalsabilla Novel

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, West Sumatra, Indonesia

Rismi Verawati

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, West Sumatra, Indonesia

Amalia Putri Lubis

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, West Sumatra, Indonesia

Vikash Jakhmola

Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India

Meksim Rebezov

Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, ۲۶ Talalikhin Str., Moscow ۱۰۹۳۱۶, Russia

Syafrizal Syafrizal

Department of Animal Husbandry, Faculty of Agricultural, Universitas Tamansiswa Padang, Indonesia

Shafique Ahmed

Department of Biological Sciences, Faculty of Allied Health Sciences, Faculty of Allied Health Sciences, The Superior University, Lahore, Pakistan

Mishra Lakshmi

International School of Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

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