A simple, convenient three component one-pot procedure for the synthesisof benzimidazolo-quinazolinone derivatives in the presenceSilica-based sulfonic acid (MCM- 41-SO3H)

A variety of quinazolinones are readily prepared via one-pot three-component reaction in good to excellent yields. The desired products were obtained from the reaction of dimedone, various aldehydes with 2-aminobenzimidazole under mild reaction conditions usingMCM- 41-SO3H as an effective and the reusable catalyst in refluxing ethanol has been developed. Starting from the corresponding available materials, this friendly and environmentally free-metal procedure has been successfully extended to the synthesis of benzimidazoquinazolinones. The salient advantages of this method are mild reaction conditions, nontoxic and inexpensive catalyst, environmentally benign, high to excellent yields, shorter reaction times, easy operation, and no column chromatographic separation.