Intrauterine administration of recombinant human chorionic gonadotropin before embryo transfer on outcome of in vitro fertilization/ intracytoplasmic sperm injection: A randomized clinical trial
محل انتشار: مجله طب تولید مثل ایران، دوره: 12، شماره: 1
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 426
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شناسه ملی سند علمی:
JR_IJRM-12-1_001
تاریخ نمایه سازی: 16 شهریور 1395
چکیده مقاله:
Background: The direct effect of hCG on the human endometrium was studied several times. Objective: The objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET). Materials and Methods: In this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoing their first in vitro fertilization/ intracytoplasmic sperm injection (IVF-ICSI) cycles were randomly assigned to receive 250μg intrauterine rhCG (n=84) or placebo (n=98) before ET. The implantation and pregnancy rates were compared between groups. Results: Patients who received intrauterine rhCG before ET had significantly higher implantation (36.9% vs. 22.4%; p=0.035), clinical pregnancy rates (34.5% vs. 20.4%; p=0.044) and ongoing pregnancy rate (32.1% vs. 18.4%; p=0.032) when compared to those who received placebo. The abortion (2.4% vs. 2.0%; p=0.929) and ectopic pregnancy rates (1.2% vs. 1.0%; p=0.976) were comparable between groups of rhCG and placebo, respectively. Conclusion: Intrauterine injection of 250μg of rhCG before ET significantly improves the implantation and pregnancy rates in IVF/ICSI cycles.
کلیدواژه ها:
Recombinant human chorionic gonadotropin (rhCG) ، Intracytoplasmic sperm injection (ICSI) ، In vitro fertilization (IVF) ، Implantation rate ، Pregnancy rate
نویسندگان
Afsoon Zarei
Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Ebrahim Parsanezhad
Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
Masoumeh Younesi
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Saeed Alborzi
Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.