Effect of Magnesium Sulfate on Hemodynamic Changes During Sternotomy and Laryngoscopy inCoronary Artery Bypass Graft Surgery: A Randomized Clinical Trial

Background: This study was designed to evaluate the effectiveness of low and high dose magnesium sulfate inreducing pressure responses to laryngoscopy and sternotomy.Methods: A total of 90 patients were assigned into three groups. The patients in Group L received a 20 mg/kgbolus dose of magnesium sulfate 3 minutes before intubation followed by an infusion of magnesium sulfate (10mg/kg/h) in contrast to 40 mg/kg of magnesium sulfate followed by an infusion of 20 mg/kg/h magnesiumsulfate administered to Group H. Patients in Group P received saline as placebo. Heart rate and mean arterialpressure (MAP) recorded at the baseline were noted down again before intubation and 30 seconds, 2 and4 minutes after intubation and 1 minute before, and 30 seconds, 2 and 4 minutes after sternotomy.Results: MAP in Groups L and H compared to Group P was significantly lower, after intubation (P = 0.0040).The difference between MAP in Groups L and H was only statistically significant 30 seconds after intubation.MAP 30 seconds and 2 minutes after sternotomy was statistically different between Groups L and H comparedto Group P. The difference between Groups H and P was only statistically significant before sternotomy and4 minutes after sternotomy (P = 0.0001).Conclusions: A low dose magnesium sulfate attenuates the hemodynamic response to laryngoscopy andsternotomy in coronary artery bypass graft surgery.© 2014 Tehran University of Medical Sciences. All rights reserved.Citation: Marashi SM, Azimaraghi O, Hejazian-Yazdi A, Movafegh A. Movafegh A. Effect of Magnesium Sulfate on Hemodynamic Changes During Sternotomy and Laryngoscopy in Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial, Acad J Surg,, 2016; 3(1-2): 19-23.