META-ANALYSIS STUDY FOR ANTIBIOTIC RESISTANCE OF CITROBACTER FREUNDII CLINICAL ISOLATES

Background and Aim:Citrobacter freundii causes opportunistic infections in hospitalized patients, especially in intensive care units (ICUs). The prevalence of antibiotic resistant Citrobacter freundii is increasing in world, and this may cause significant clinical problems.Methods:this study aimed to evaluate the rate of antibiotic resistance of Citrobacter freundii using meta-analysis. Eight qualified antibiotic were analyzed by using random effects model Meta-analysis method and with the software STATA Ver.12.0.Results:The highest and lowest resistances were found against piperacillin and imipenem, respectively. This study showed that Citrobacter freundii strains shave resistance to a wide range of antimicrobial agents.Conclusion:According to the importance of these bacteria in nosocomial infections particularly in intensive care units, it is necessary to apply appropriate strategies to control the spread of C.freundii