Effects of Ramadan Fasting on Plasma Free Fatty Acids in Patients with Non-alcoholic Fatty Liver Disease

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a global heabol health concern with the prevalence rate of 10-35% . Several factors are in the pathogenesis of NAFLD. This study aimed to evaluate the effects of Ramadan fasting on plasma free fatty acids in patients with NAFLD. Methods: This cross-sectiona study was conducted on 50 NAFLD patients in the holy month of Ramadan during June-July 2014 (Islamic year: 1435) in Mashhad, Iran. patients were classified into two grups with body mass index (BMI) of< (n=23) and> 30 hg/m2 (n=27). Participants were within the age range of 18-65 years. Inclusion criteria were NAFLD patients with fatty liver diagnosis in ultrasound and minimum fasting duration of 23 days in Ramadan. Levels of plasma free fatty acids (palmitic, elaidic, and oleic fatty acid) were assessed in the blood samples of all patients using gas chromatography with flame ionization detection (GC-FID). Results: No significant changes were observed in the plasma levels of palmitic, elaidic and oleic fatty acids in overweight patients (BMI: 25-30 kg/m2). However, plasma levels of elaidic acid significantly increased in obese patients (P<0.001). Conclusion: According to the results of this study, adherence to the principles of Ramadan fasting could enhance the health status of NAFLD patients. However, it is recommended that future studies be conducted in this regard.