Determination of Amitriptyline using Bromate-Bromide and two Dyes

Spectrophotometric studies were successfully used in quantitative analysis of Amitriptyline Hydrochloride(ATH) Two new methods using spectrophotometry are described for the determination of (ATH) withpotassium bromate as the oxidizing agent and acid dyes, Methyl orange and Indigo carmine. Bothspectrophotometric methods are based on the oxidation of mentioned drugs by a known excess of bromate inacid medium and in the presence of excess of bromide followed by estimation of surplus oxidant by reactingwith either Indigo carmine (method A) or Methyl orange (method B), and measuring the absorbance at 609 or507nm