The relation between the vascular formation and cellular proliferation with gender and age in oral squamous cell carcinoma (OSCC)
محل انتشار: هفدهمین همایش سالانه آسیب شناسی و طب آزمایشگاه
سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 338
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شناسه ملی سند علمی:
ACPLMED17_001
تاریخ نمایه سازی: 20 آبان 1397
چکیده مقاله:
Background:Cell proliferation and new blood vessels formation are critical factors in metastasis and prognosis of malignant tumors.The relation between metastasis and prognosis with gender and age is not elucidated. Aim: The aim was to study the relation between the vascular formation and cellular proliferation with gender and age in Oral Squamous Cell Carcinoma(OSCC). Materials and Methods:The study was retrospective.24 paraffin-embedded samples of well differentiated OSCC was detected immunohistochemically for Vascular Endothelial Growth Factor (VEGF) and Ki67 expression.The Labelling Index(LI:positive epithelial cells/1000 epithelial cells) of VEGF and Ki67 positive cells were obtained.The correlation between VEGF and Ki67 expression with gender and age was determined . The linear regression and spearman tests were used for statistical analyzing. Results:The correlation between VEGF expression with gender and age was not significant(p=0.67 and p=0.88,respectively).The correlation between Ki67 expression with gender and age was not significant (p=0.43 and p=0.88,respectively). Conclusion:Blood vessels formation and cell proliferation are not related to gender and age in OSCC.
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نویسندگان
Noushin Jalayer Naderi
Associate Professor. Department of Oral and Maxillofacial Pathology, Faculty ofDentistry, Shahed University
Farrokh Tirgari
Associate Professor. Pathology Dept.,Institute Cancer , Tehran University of Medical Sciences