Abrupt development of plasma cell leukemia in a patient with chronic anemia under follow up

Plasma cell leukemia (PCL) is a very rare and progressive hematologic malignancy with unpleasant prognosis which present with monoclonal proliferation of plasma cells in peripheral blood firstly. Here we report a 52 years old female case of PCL which diagnosed by morphology and immunohistochemistery (IHC) study. IHC revealed CD20+/CD38+/CD138+/CD56-/kappa-/lambda+. We diagnose PCL on peripheral blood. IHC can be helpful for prognostic determination.