Hodgkin s lymphoma accuring in Warthin s tumor: A case report

Background:Warthin s tumor (WT) is the second most common type of salivary gland tumors. Microscopically, Warthin s tumor displays a proliferative epithelial component and lymphoid stroma. The Hodgkin s lymphomas associated with Warthin s tumor are extremely rare. Case Report: Here, we report the simultaneous occurrence of classical Hodgkin s lymphoma and WT in a 55-year-old male patient whose symptoms included an enlargement of the left parotid gland. Upon parotidectomy, the tissue specimenshowed a WT with extensive replacement of the lymphoid stroma by a large number of eosinophils, plasma cells, and atypical mononuclear cells admixed with classicReed-Sternberg cells.Immunohistochemical examination showed that Reed- Sternberg cells expressed positivity for CD15 and CD30. Conclusion: The lymphoid stroma in WT is part of the systemic lymphoid tissue and thus may be involved by the lymphoma. This case serves as a reminder that a careful evaluation of the histomorphological and immunohistological features of the lymphoid tissue is required for a WT biopsy.