Facile and Efficient Multicomponent Synthesis of Some Trisubstituted 1,3,5-Triazine Derivatives Catalyzed by Various Nanocatalysts

1,3,5-triazine derivatives have played a distinguished role in medicinal and biological chemistry. These derivatives have participated in the structure of some novel potentchemicals showing diverse medicinal effects such as 5-HT6 serotonin receptor agonists [1], antimycobacterial and antimicrobial agents [2]. Therefore, the multicomponent synthesis of 1,3,5-triazine derivatives under novel green conditions using magnetic Fe2O3-MCM-41 and modified zeolite nanocatalysts was studied in the present research study (Fig. 1). This protocol has been previously examined under uncatalyzed conditions [3,4]. The most important drawbacks of these previous methods include long reaction times and low to moderate yields of the products Our introduced procedure led to the formation of ther desired 1,3,5-triazine derivatives with a broad range of substitutes at positions 2, 4 and 6 of the ring. Moreover, the reactions were proceeded smoothly under the defined reaction conditions and the products were obtained within short reaction times and good to excellent yields. The products were also easily purified without using laborious purification methods by aqueous dilution of the reaction mixture