Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus
محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 9، شماره: 3
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 582
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شناسه ملی سند علمی:
JR_AJP-9-3_004
تاریخ نمایه سازی: 7 خرداد 1398
چکیده مقاله:
Objective: Acanthus syriacus (AS) is one of the valuable herbal plants with immunomodulatory potentials. The aim of this study is to assemble a phytochemical investigation of A. syriacus exploring its anti-inflammatory and antinociceptive properties, identification of its most active compound(s) and elucidating their structure and determining their mechanisms of action. Materials and Methods: Bio-guided fractionation and isolation-schemes were used utilizing RP-HPLC, CC, 1H- and 13C-NMR, and biological-models were used to evaluate their effects against inflammation and neuropathic-pain (NP). Results: The outcomes showed that the most active fraction (FKCA) of AS was identified. Two of the three components of FKCA were identified by chromatographic-methods, while the third compound was isolated, its structure was elucidated and its was named Kromeic acid (KRA); FKCA contained Ferulic acid (27.5%), kromeic acid (48.1%), and chlorogenic acid (24.4%). AS, FKCA and KRA showed significant (p˂0.05) anti-inflammatory and antinociceptive potentials in the management of allodynia and thermal-hyperalgesia in NP. AS and FCKA showed comparatively equipotent antinociceptive-effects. FKCA showed higher antinociceptive effects than KRA suggesting additive-effects among FKCA components. The anti-inflammatory, insulin secretagogue, oxidative-stress reducing, and protective effects against NO-induced neuronal-toxicity might be amongst the possible mechanisms of tested compounds to alleviate NP. Conclusion: Here, we report the isolation and structure elucidation of a novel quinic-acid derivative, KRA. A. syriacus, FKCA, and KRA might be used as a novel complementary approach to ameliorate a variety of painful-syndromes.
کلیدواژه ها:
Novel quinic acid derivative ، Acanthus syriacus ، Anti-inflammatory ، antinociceptive effects ، Kromeic acid
نویسندگان
Karim Raafat
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, ۱۱۵۰۲۰ Beirut, Lebanon
Mohammad Mehdi Heidari
Department of Biology, Faculty of Science, Yazd University, Yazd, Iran
Mehri Khatami
Department of Biology, Faculty of Science, Yazd University, Yazd, Iran
Vahideh Ghorani
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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