Correlation of the metabolic syndrome with IL-27 in schizophrenia patients
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 424
فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JNFH-7-1_002
تاریخ نمایه سازی: 11 تیر 1398
چکیده مقاله:
Introduction: Growing evidence suggests that antipsychotic drugs affect the level of cytokines and metabolic syndrome parameters in schizophrenic patients. The present study aimed to investigate the serum markers of metabolic syndrome, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), fasting blood sugar (FBS),total cholesterol, and insulin, and interleukin-27 (IL-27) in the patients with schizophrenia and compared the levels with healthy subjects. Methods: In this cross-sectional study, the serum level of IL-27 was measured in 45 patients with schizophrenia and 45 healthy subjects using the ELISA. In addition, the markers of metabolic syndrome were measured in Dr. Salehi Laboratory in Yasouj, Iran. Data analysis was performed in SPSS version 21. Results: A significant increase was observed in IL-27 in the patients with schizophrenia (P= 0.043) compared to the healthy controls. Evaluation of the risk factors of metabolic syndrome in schizophrenic patients compared to the controls indicated no significant differences in the body mass index (P=0.764), systolic blood pressure (P=0.670), diastolic blood pressure (P=0.216), total cholesterol (P=0.103), TG (P=0.097), and LDL (P=0.255). However, the serum levels of HDL (P=0.012) and insulin (P=0.001) significantly decreased and increased, respectively in schizophrenic patients compared to the controls. Moreover, a strong, positive correlation was observed between the levels of insulin and LDL andIL-27, with the correlation-coefficients of 0.312 and 0.641, respectively. A negative correlation was also denoted between IL-27 and HDL with the correlation-coefficient of -0.413 (P=0.005). The associations between IL-27 and the other markers of metabolic syndrome were not considered significant. Conclusion: According to the results, changes in IL-27 may affect the Pathophysiology of schizophrenia. Antipsychotic therapy has been reported to increase the serum levels of IL-27, which in turn exacerbate and increase the incidence of metabolic disorders.
کلیدواژه ها:
نویسندگان
Salar Andarzi
Department of genetics, Faculty of Sciences, University of Shahid Chamran Ahvaz, Ahvaz, Iran
Salah Hajinejad
Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
Hamidreza Miri
Department of Laboratory Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran | Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :