Otitis Media with Effusion in Children and the Impact of Risk Factors on Serum Cytokine Levels

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 361

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شناسه ملی سند علمی:

JR_IJOTO-29-2_003

تاریخ نمایه سازی: 12 تیر 1398

چکیده مقاله:

Introduction:To evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (OME) Materials and Methods:We investigated serum levels of interleukins (IL)-4, IL-5, and IL-13, along with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), by enzyme-linked immunosorbent assay (ELISA) in 35 children with OME and 28 healthy controls. Results:Children with OME had significantly higher levels of IL-5 in comparison with the control group, ranging from 1 pg/ml in cases to 0.04 pg/ml in controls (P=0.009). However, after adjusting for confounding variables, there was no significant difference in serum levels of IL-13, IL-4, IFN-γ, or TNF-α between the two groups (P=0.287, P=0.627, P=0.793, and P=0.217, respectively) Conclusions:The findings of this study suggest that in comparison with the control group, serum IL-5 levels were elevated in OME cases.

کلیدواژه ها:

Interleukins ، Inflammatory cytokines ، Otitis media with effusion ، Pediatrics

نویسندگان

Saba Arshi

Department of Allergy and Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran.

Fatemeh Dehghani-Firouzabadi

ENT and Head and Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences,Tehran,Iran.

Babak Ghalehbaghi

ENT and Head and Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences,Tehran,Iran.

Ali Dehghani-Firouzabadi

Department of Health, Epidemiologist, Mississippi State, United States.

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