mRNA level of FSHR gene as a biomarker in PCOs patients

Background: Selecting good quality oocyte and embryo with high implantation potential is of great importance in assisted reproductive technologies (ART). To date, the choice of the best oocyte and embryo for transfer have been based on morphological parameters. Therefore, movement towards modern technologies such as genomics, transcriptomics, proteomics and metabolomics to select the most competent oocytes and/or embryos with the greatest implantation potential would be significant.Objective: We aimed to assess the FSHR gene expression of cumulus cells (CCs) between mature and immature oocyte in order to evaluate oocyte maturity in PCOs patient.Materials and Methods: The CCs were retrieved from 30 PCO women and divided into groups of GV and MII according to the nuclear maturity status in order to studying expression patterns of FSHR gene using Q-PCR.Results: There were significant differences (p<0.05) in mRNA levels of FSHR gene between the groups.Conclusion: It appears the expression level of these genes in cumulus cells have the potential to be a predictive non-invasive biomarker for oocyte maturity and quality.