Hepatoprotective activity of Mammea africana ethanol stem bark extract

سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 293

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شناسه ملی سند علمی:

JR_AJP-6-2_012

تاریخ نمایه سازی: 1 مهر 1398

چکیده مقاله:

Mammea africana Sabine (Guttiferae) stembark, a common plant, traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol- induced liver injury in rats. The hepatoprotective effect of the stembark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters: total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver. The administration of the stembark extract caused significant (p

نویسندگان

Jude Efiom Okokon

Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

Michael Burata Bawo

Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

Herbert Orji Mbagwu

Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

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