The Effects of in ovo Nanocurcumin Administration on Oxidative Stress and Histology of Embryonic Chicken Heart
محل انتشار: مجله علوم طیور، دوره: 5، شماره: 2
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 353
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شناسه ملی سند علمی:
JR_PSJG-5-2_004
تاریخ نمایه سازی: 17 مهر 1398
چکیده مقاله:
This study was designed to evaluate the effects of nanocurcumin (NC) on oxidative stress and histology of embryonic chicken heart. NC was injected into the yolk of 4-day-old embryonic eggs at one of three doses: 10 ppm (NC10 group), 100 ppm (NC100 group), and 1000 ppm (NC1000 group). The control group received normal saline. Oxidative stress in heart tissue was evaluated by measuring malondialdehyde (MDA) concentration, glutathione (GSH) content, and ferric reducing antioxidant power (FRAP). Serum lipids and cardio-histolopathogy were also measured. There were no significant differences in GSH, FRAP, and MDA levels between the control and treatment groups (P > 0.05). The serum lipid profile was altered in the NC100 group, with reduced levels of triglyceride (TG) (P < 0.01) but higher levels of HDL-c (P < 0.01) compared to the control. Heart histology was similar between NC10 and NC100 treatments compared to the control group. However, heart sections in NC1000 revealed focal areas of disrupted cardiac muscles and mild infiltration of mononuclear inflammatory cells between muscle fibers. It was concluded that NC at a concentration of 100 ppm did not damage heart tissues in chicken embryo and could be used as a valuable molecule for cardiovascular disease prevention.
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نویسندگان
Araghi A
Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
Nazaktabar A
Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
Sayrafi R
Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
Salehi A
Department of Food Safety and Hygiene, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
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