Evaluation of Correlation Between T Helper Cells and Myasthenia Gravis

Myasthenia gravis (MG) mostly is an autoimmune disease, which the white blood cells start producing antibodies against the site of the nerve to the muscle, for reasons that are often unclear. The prevalence of this disease in different regions of Iran varies from 53 to 74 per 100000 people. T helper cells ( Th cells ) is one of the lymphocyte T subtypes that accompanies other white blood cells in immune processes includingB cells maturation to plasmocytes and memory cells and activation of cytotoxic T cells and macrophages.The purpose of our study was to evaluate relationship between T helper cells and myasthenia gravis. We searched Pubmed, Google scholar, Cochrane, SID and ISC databases until December 2018 with myasthenia gravis, T helper cells and acetylcholine receptor keywords. By searching these databases, only 35 articles were found in Pubmed and 87 articles were found in Google scholar.From 122 articles with investigating title we exclude 98 articles and with reading abstract we exclude 16 articles.Finally we include 8 articles in to our study. Our findings demonstrated that certain subsets of T helper cells are involved in the pathogenesis of MG, including Th1 and regulatory T cells ( Treg ). However Th17 cells which recently areidentified have an important role in developing MG, it’s prognose is still unknown.In one article, the increasing Th17 cells perhaps manifest the severity of disease that is valuable in the diagnosis and therapeutic strategy choice for patients with MG. Conclusion: There is a significantpositive correlation between frequency of Th17 cells and anti-acetylcholine receptor antibodies concentration in MG patients. It is proposed to reconstruct the balance of T helper subsets to become a new therapeutic goal for MG. Although more studies are needed in this context.