Preparation and Characterization of an Optimum Famotidine Oro Disintegrating Tablet
محل انتشار: کنفرانس بین المللی طب ایرانی اسلامی
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 474
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شناسه ملی سند علمی:
BCNF01_051
تاریخ نمایه سازی: 19 آذر 1398
چکیده مقاله:
Over the past three decades, orally disintegrating tablets (ODTs) have gained much attention as a preferred alternative to conventional oral dosage forms such as tablets and capsules. An ODT is a solid dosage form that disintegrates and dissolves in the mouth without water .The purpose of the present study was to prepare orally disintegrated tablet of famotidine. Natural materials have advantages over synthetic ones since they are chemically inert, non-toxic, less expensive, biodegradable and widely available. It is proved from the studies that natural polymers are more safe and efficacious than the synthetic polymers.In this investigation we compared the efficacy of natural disintegrants such as plantago ovata and cucurbita maxima with chemical ones such as crosscarmellose, and sodium starch glycolate, for preparation of desirable famotidine ODTs. The tablets were evaluated for weight variation, hardness, friability, assay, disintegration time, palatability and in-vitro dissolution study. The best formulation was composed of mannitol ,sodium croscarmellose (3%),magnesium stearate (1%) and sodium saccharin (3%). The tablets had 19.3N hardness, 0.9% friability and disintegrated in 7.3 seconds.
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نویسندگان
Narges Shams
Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran,Iran
Seyed Alireza Mortazavi
Department of Pharmaceutics, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran,Iran
Mahdieh Farhangi
pharmaceutics Phd, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran,Iran