LP-10 identified from protein hydrolysate white grub larvae exhibiting an inducing effect on antioxidant enzyme activities in human lung carcinoma cell line of A549
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 351
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شناسه ملی سند علمی:
THCONF02_458
تاریخ نمایه سازی: 30 دی 1398
چکیده مقاله:
In this study, Protein Hydrolysate White grub larvae was fractionized by reversed phase highpressure liquid chromatography (RP-HPLC). The sequences one of the peptide fractions were identified by tandem mass spectrometry and named as LP-10. Antioxidant activity and cellular effect of synthetic peptides on A549 cell line were investigated. Results showed that by increasing of peptide concentrations induced significantly (P < 0.01) activities of superoxide dismutase and glutathione peroxidase. Different peptide concentrations exhibited a quantitative hemolytic activity. At the highest concentration, only 6.56% of hemolysis were observed. Our results suggested that the peptides of white grub larvae, possessed an inducing effect on increase of antioxidant enzyme activities in A549 cells.
کلیدواژه ها:
Peptide. Antioxidant enzyme. Superoxide dismutase. Glutathione peroxidase
نویسندگان
Asal khajepour
Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran,
Hossein Naderi-Manesh
Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran,
Ahmad Asoodeh
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran