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مقالات فارسیISIکنفرانسهاژورنالها

Preparation and quality control of 177Lu-chitosan for radiosynovectomy

محل انتشار: مجله پزشکی هسته ای ایران، دوره: 22، شماره: 1
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 372

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لینک ثابت به این مقاله:
https://civilica.com/doc/986619

شناسه ملی سند علمی:

JR_IRJNM-22-1_001

تاریخ نمایه سازی: 21 بهمن 1398

چکیده مقاله:

Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Several radiopharmaceuticals have been developed for RSV so far, but still development of new radiophamaceuticals is of crucial interest. In this research, the 177Lu-chitosan complex (177Lu-CHITO) was introduced as a new agent for RSV. Methods: 177Lu was produced by irradiation of a natural Lu2O3 target at a thermal neutron flux of approximately 4 × 1013 n/cm2·s. 177Lu-CHITO was prepared in the diluted acetic acid solution. The radiochemical yield was checked by ITLC method. The biodistribution of the complex was investigated by intra-articular injection to rabbits’ and rats’ knee joints. The leakage of injected dose from the injection site in the rabbit organs was investigated using SPECT imaging up to 48 hours. Results: 177Lu was prepared with a specific activity of 2.6-3 GBq.mg-1 and radionuclide purity of 99.98%. 177Lu-CHITO was prepared successfully with high radiochemical purity (95%) and specific activity of 888 TBq/mmol. Both the biodistribution data in rats and SPECT imaging of the rabbit showed that there was no significant leakage of the injected activity even after 192 h. Conclusion: Considering all of the excellent features of the complex, this radiopharmaceutical can be used for effective management of synovial inflammation.

کلیدواژه ها:

Chitosan ، Radiosynovectomy ، Lu-177 ، Biodistribution ، SPECT

نویسندگان

Hassan Yousefnia

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran (AEOI), Tehran, Iran

Amir Jalilian

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran (AEOI), Tehran, Iran

Fereydoun Abbasi-Davani

Radiation Application Group, Faculty of Nuclear Engineering, Shahid Beheshti University, Tehran, Iran

Samaneh Zolghadri

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran (AEOI), Tehran, Iran

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