A Comparative Study in Influence of Isoflurane and Propofol on IL-1, IL-6, TNF-α Serum Levels after Craniotomy for Supratentorial Brain Tumors
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 374
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شناسه ملی سند علمی:
JR_SBMU-4-1_003
تاریخ نمایه سازی: 6 اسفند 1398
چکیده مقاله:
Background: The purpose of this randomized, single-center study was to prospectively investigate the impact of anesthetic techniques for craniotomy on the release of cytokines (interleukin (IL)-1, IL-6, tumor necrosis factor factor-alpha (TNF-α)) and to determine whether intravenous anesthesia compared to inhalational anesthesia attenuates the inflammatory response.Methods and Materials: The study enrolled 60 patients undergoing craniotomy, allocated into two equal groups to receive either Isoflurane (n=30) and Propofol (n=30). Non-invasive hemodynamic monitoring was used. Serum levels of IL-1, IL-6 and TNF-α were evaluated before and at the end of surgery and anesthesia.Results: Although there was a significant rise in serum level of inflammatory cytokine but compared with patients anaesthetized with Isoflurane, patients who received Propofol had significant lower levels of IL-1, IL-6 and TNF-a after surgery (p<0.05).Conclusion: Patients who received Propofol had lower levels of IL-1, IL-6 and TNF-α after surgery. Our findings should incite future studies to prove a potential medically important anti-inflammatory role of Propofol in neuroanesthesia.
کلیدواژه ها:
نویسندگان
Farhad Safari
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Parisa Sezari
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Kamran Mottaghi
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Bahareh Torbat Isfahani
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Masoud Nashibi
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran