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مقالات فارسیISIکنفرانسهاژورنالها

Purification of PIA and rSesC as Putative Vaccine Candidates Against Staphylococcus aureus

محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 8، شماره: 2
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 224

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لینک ثابت به این مقاله:
https://civilica.com/doc/1141931

شناسه ملی سند علمی:

JR_RBMB-8-2_009

تاریخ نمایه سازی: 22 دی 1399

چکیده مقاله:

Background: Staphylococcus aureus is predominant at sites of biomaterial-associated infection (BAI) and frequently infects hospitalized individuals. Methods: The polysaccharide intercellular adhesin (PIA) and S. epidermidis rSesC protein, major macromolecules in biofilm formation, were purified under native conditions and cloned and expressed in a prokaryotic host. Results: Purification of the macromolecules was confirmed by FTIR and Western blotting. Conclusions: The S. epidermidis SesC protein and PIA were successfully purified. Both are considered as vaccine candidates.

کلیدواژه ها:

Biofilm formation ، Polysaccharide Intracellular Adhesin ، Staphylococcus aureus.

نویسندگان

Sara Bahonar

Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science. & Molecular and cell biology Research center, Faculty of Medicine, Mazandaran University of Medical sciences, Sari, Iran.

Maryam Ghazvinian

Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science.

Mohamad Reza Haghshenas

Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science.

Hamid Reza Goli

Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science.

Bahman Mirzaei

Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Science. & Molecular and cell biology Research center, Faculty of Medicine, Mazandaran University of Medical sciences, Sari, Iran.