Modification of Creatinine to Form New Oxazepane Ring and Study Their Antioxidant Activity

In this research new creatinine Schiff bases (۱a, ۱b, and ۱c) were synthesized from the reaction of aromatic aldehydes (۴-nitrobenzaldehyde,۴-amino benzaldehyde, and cinnamaldehyde) with creatinine, in few drops of glacial CH۳COOH as a catalyst in C۲H۵OH. Then, seven-member rings were prepared (oxazepine) (۲a-۴c) on creatinine form treatment of imines with (phthalic, maleic, and succinic anhydrides. Synthesized compounds were identified by IR, melting point, and ۱H-NMR of some of them. Some of the prepared compounds were studded with antioxidant activity.