ورود
مقالات فارسیISIکنفرانسهاژورنالها

The effects of dried root aqueous extract of Salvia miltiorrhiza and its major ingredient in acceleration of orthodontic tooth movement in rat

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 18، شماره: 10
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 127

فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1297031

شناسه ملی سند علمی:

JR_IJBMS-18-10_015

تاریخ نمایه سازی: 3 آبان 1400

چکیده مقاله:

Objective(s): Salvia miltiorrhiza (SM) is a popular and classic herb in traditional Chineses medicines. The objective is to confirm the effects of aqueous extract of S. miltiorrhiza (ESM) and its main ingredient on the promotion of orthodontic tooth movement and healing of periodontal ligament in rat. Materials and Methods: Male Sprague-Dawley rats (n= ۱۵۰) were divided into five groups: model control group (۰.۵ ml/kg phosphate-buffered saline (PBS) injection), ESM group (۰.۷۵ g/kg/day of crude drugs) and Danshensu subgroups (۲۵۰, ۵۰۰, ۷۵۰ mg/kg/day of body weight). All rats were administered intramuscularly into the buccal vestibular mucosa of first molar of left maxillary. The indicators such as the moving distance of orthodontic tooth, nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) expression and osteoclasts were tested. Results: The expressions of RANKL and OPG in the treatment groups were obviously enhanced compared with control group (P<۰.۰۵). The increase rate of OPG expression was slower than that of RANKL. But, RANKL decreased conspicuously after no orthodontic pressure was applied, especially in the treatment groups (Danshengsu high dose group at day ۳۰: ۲.۱۷ versus ۳.۴۷ of control, P<۰.۰۱). ESM groups promoted osteoclasts proliferation in the first ۲۰ days. Conclusion: There is a relationship between RANKL/OPG ratio and the number of osteoclasts. ESM might accelerate periodontal alteration of rat orthodontic tooth via producing more osteoclasts.

کلیدواژه ها:

Danshensu ، Movement distance ، Osteoclasts ، Osteoprotegerin ، Receptor activator for nuclear factor κB ligand

نویسندگان

Li-qun Xiao

Department of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People&#۰۳۹;s Hospital, Yichang ۴۴۳۰۰۳, China

Hong-tao Wang

Department of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People&#۰۳۹;s Hospital, Yichang ۴۴۳۰۰۳, China

Yu-lan Li

Department of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People&#۰۳۹;s Hospital, Yichang ۴۴۳۰۰۳, China

Qing Zeng

Department of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People&#۰۳۹;s Hospital, Yichang ۴۴۳۰۰۳, China

E Zhou

Department of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People&#۰۳۹;s Hospital, Yichang ۴۴۳۰۰۳, China

Xia Ni

Department of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People&#۰۳۹;s Hospital, Yichang ۴۴۳۰۰۳, China

Zhong-ping Huan

Department of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People&#۰۳۹;s Hospital, Yichang ۴۴۳۰۰۳, China

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Xue H, Zheng J, Cui Z, Bai X, Li G, ...
  • Yan ZQ, He WL, Zou SJ. Research progress on effect ...
  • Ekizer A, Uysal T, Güray E, Akkuş D. Effect of ...
  • Li F, Li G, Hu H, Liu R, Chen J, ...
  • Jin SD, Zheng R, Wu LP, Yang DH. Effect of ...
  • Chen F, Wang XX, Zhou YL, Li T, Zhang J. ...
  • Mei YS, Jia YL, Zhang LN, Jin SM, Zhang J. ...
  • Zhang WJ, Lin XF, Ai BY, Zhang J. The effect ...
  • Chen F, Wang XX, Zhou YL, Li T, Zhang J. ...
  • Ding Y, Chen H, Xu RS. The study of Salvia ...
  • Wang Y, Wang XX, Zhang LN, Jin SM, Zhang J. ...
  • Zhang JL, Cui M, He Y, Yu HL, Guo DA. ...
  • Ren Y, Maltha JC, Kuijpers-Jagtman AM. The rat as a ...
  • Yamaguchi M. RANK/RANKL/OPG during orthodontic tooth movement. Orthod Craniofac Res ...
  • Noxon SJ, King GJ, Gu G, Huang G. Osteoclast clearance ...
  • Storey E. The nature of tooth movement. Am J Orthod ...
  • Krishnan V, Davidovitch Z. Cellular, molecular, and tissue-level reactions to ...
  • Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, ...
  • Wong BR, Rho J, Arron J, Robinson E, Orlinick J, ...
  • Yasuda H, Shima N, Nakagawa N, Mochizuki SI, Yano K, ...
  • Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, ...
  • Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, ...
  • Morony S, Capparelli C, Lee R, Shimamoto G, Boone T, ...
  • Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, ...
  • Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, ...
  • Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T ...
  • Schoppet M, Preissner KT, Hofbauer LC. RANK ligand and osteoprotegerin: ...
  • Kwak HB, Yang D, Ha H, Lee JH, Kim HN, ...
  • Kim HH, Kim JH, Kwak HB, Huang H, Han SH, ...
  • Nimeri G, Kau CH, Abou-Kheir NS, Corona R. Acceleration of ...
  • Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling ...
    • نمایش کامل مراجع