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Pantoprazole, a proton pump inhibitor, increases orthodontic tooth movement in rats

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 17، شماره: 6
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 113

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https://civilica.com/doc/1297907

شناسه ملی سند علمی:

JR_IJBMS-17-6_009

تاریخ نمایه سازی: 4 آبان 1400

چکیده مقاله:

Objective(s):Pantoprazole, is a proton pump inhibitor (PPI) prescribed for the treatment of upper gastrointestinal disorders, which in high doses has been suggested to decrease calcium absorption leading to hypocalcaemia and therefore osteoporosis. The aim of this study was to assess whether pantoprazol, could alter the rate of orthodontic tooth movement (OTM) in rats. Materials and Methods: A time course study was established using ۷۲ rats which were divided into six groups of ۱۲ samples each (four: vehicle; eight: pantoprazole + vehicle). Pantoprazole at a dose of ۲۰۰ mg/kg suspended in carboxymethyl cellulose (۰.۲۵ percent) was administered by a gastric tube. The upper incisors and first molars were ligated by a ۵ mm nickel-titanium closed-coil spring to deliver an initial force of ۶۰ g. Animals were euthanized two weeks after orthodontic treatment followed by assessment of tooth movement and histomorphometric evaluation of the detached maxillae. Lateral skull radiographs were obtained once a week, starting from the first day to the ۶th week of the study. OTM and bone density data were analyzed using independent sample t-test and repeated measures ANOVA. Results: No significant changes in OTM measurements and optical density were observed in vehicle-receiving animals during the study (P=۰.۹۹۴). OTM was significantly increased after six weeks pantoprazole therapy which continued until the ۷th week of the experiment (P=۰.۰۰۷). Optical density significantly increased in the pantoprazole-treated rats after six weeks. Conclusion: Long term PPI therapy at high doses could lead to osteoporosis and enhanced OTM.

کلیدواژه ها:

Pantoprazole ، Proton pump inhibitors ، Radiography ، Rats ، Tooth movement

نویسندگان

Mohsen Shirazi

Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Orthodontics, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Houman Alimoradi

Department of Pharmacology and Toxicology, University of Otago, P.O. Box ۹۱۳, Dunedin, New Zealand

Yasaman Kheirandish

Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Shahroo Etemad‐Moghadam

Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran

Mojgan Alaeddini

Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran

Alipasha Meysamie

Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Seyed Amir Reza Fatahi Meybodi

Department of Orthodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Ahmad Reza Dehpour

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

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  • ۱.Stedman CA, Barclay ML. Review article: comparison of the pharmacokinetics, ...
  • ۲.Horn J. The proton-pump inhibitors: similarities and differences. Clin Ther. ...
  • ۳.Jung HK. Is there any association of osteoporosis with proton ...
  • ۴.Yang YX, Lewis JD, Epstein S, Metz DC. Long-term protons ...
  • ۵.Coté GA, Howden CW. Potential adverse effects of proton pump ...
  • ۶.Robertson DJ, Larsson H, Friis S, Pedersen L, Baron JA, ...
  • ۷.Kobayashi Y, Takagi H, Sakai H, Hashimoto F, Mataki S, ...
  • ۸.Norevall LI, Forsgren S, Matsson L. Expression of neuropeptides (CGRP, ...
  • ۹.Sprogar S, Meh A, Vaupotic T, Drevensek G, Drevensek M. ...
  • ۱۰.Shirazi M, Ameri A, Shafaroodi H, Motahhary P, Saleh T, ...
  • ۱۱.Shirazi M, Dehpour AR, Jafari F. The effect of thyroid ...
  • ۱۲.Shirazi M, Khosrowshahi M, Dehpour AR. The effect of chronic ...
  • ۱۳.Shirazi M, Nilforoushan D, Alghasi H, Dehpour AR. The role ...
  • ۱۴.Wei QS, Huang L, Chen XH, Wang HB, Sun WS, ...
  • ۱۵.Araghizadeh N, Paknejad M, Alaeddini M, Minaii B, Abdollahi M, ...
  • ۱۶.Amerion M, Tahajjodi S, Mahdavi Shahri N, Nikravesh MR, Jalali ...
  • ۱۷.Martinsen TC, Skogaker NE, Bendheim MØ, Waldum HL. Antral G ...
  • ۱۸.Talaeipour AR, Shirazi M, Kheirandish Y, Delrobaie A, Jafari F, ...
  • ۱۹.Nilforoushan D, Shirazi M, Dehpour AR. The role of opioid ...
  • ۲۰.Targownik LE, Lix LM, Leung S, Leslie WD. Proton-pump inhibitor ...
  • ۲۱.Nealis TB, Howden CW. Is there a dark side to ...
  • ۲۲.Roux C, Briot K, Gossec L, Kolta S, Blenk T, ...
  • ۲۳.O'Connell MB, Madden DM, Murray AM, Heaney RP, Kerzner LJ. ...
  • ۲۴.Cui GL, Syversen U, Zhao CM, Chen D, Waldum HL. ...
  • ۲۵.Melo AC, Carneiro LO, Pontes LF, Cecim RL, de Mattos ...
  • ۲۶.Ward RM۱, Kearns GL. Proton pump inhibitors in pediatrics: mechanism ...
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